Neurobiology of Disease Rbm8a Haploinsufficiency Disrupts Embryonic Cortical Development Resulting in Microcephaly
نویسندگان
چکیده
Hanqian Mao,1 X Louis-Jan Pilaz,1 John J. McMahon,1 X Christelle Golzio,2,3 X Danwei Wu,1 Lei Shi,1 Nicholas Katsanis,2,4 and X Debra L. Silver1,4,5,6 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, 2Center for Human Disease Modeling, Duke University Medical Center, Durham, North Carolina 27701, 3Department of Psychiatry and Behavioral Sciences, 4Department of Cell Biology, 5Department of Neurobiology, and 6Duke Institute for Brain Sciences, Duke University Medical Center, Durham, North Carolina 27710
منابع مشابه
Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.
The cerebral cortex is built during embryonic neurogenesis, a period when excitatory neurons are generated from progenitors. Defects in neurogenesis can cause acute neurodevelopmental disorders, such as microcephaly (reduced brain size). Altered dosage of the 1q21.1 locus has been implicated in the etiology of neurodevelopmental phenotypes; however, the role of 1q21.1 genes in neurogenesis has ...
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تاریخ انتشار 2015